Bioconjugate Therapeutics: Current Progress and Future Perspective
نویسندگان
چکیده
منابع مشابه
RNA-based therapeutics: current progress and future prospects.
Recent advances of biological drugs have broadened the scope of therapeutic targets for a variety of human diseases. This holds true for dozens of RNA-based therapeutics currently under clinical investigation for diseases ranging from genetic disorders to HIV infection to various cancers. These emerging drugs, which include therapeutic ribozymes, aptamers, and small interfering RNAs (siRNAs), d...
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Aptamer-related technologies represent a revolutionary advancement in the capacity to rapidly develop new classes of targeting ligands. Structurally distinct RNA and DNA oligonucleotides, aptamers mimic small, protein-binding molecules and exhibit high binding affinity and selectivity. Although their molecular weight is relatively small-approximately one-tenth that of monoclonal antibodies-thei...
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ژورنال
عنوان ژورنال: Molecular Pharmaceutics
سال: 2017
ISSN: 1543-8384,1543-8392
DOI: 10.1021/acs.molpharmaceut.7b00263